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Drosophila genetics has provided the Hedgehog signaling pathway with roughly ordered components, but few mechanistic connections. Several studies now show that the kinesin-related protein Costal-2 provides a physical link between the transmembrane transducer Smoothened and the transcriptional effector Cubitus interruptus.
The performance of a 4-leaf magnetic coil was evaluated during magnetic stimulation of a peripheral nerve in vitro. The site of stimulation was below the coil center, and a 90° rotation of the coil was equivalent to a change in current polarity. A hyperpolarizing magnetic stimulus failed to slow or block a propagating action potential.
Microtubules display dramatic morphological alterations from mitotic spindles to fibrous interphase structures upon exit from mitosis. In this issue of Developmental Cell, Zimmerman et al. shed a novel light on the molecular mechanism of microtubule structure reorganization during cytokinesis.
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